Hi Yao,

Thanks for your post here on the Community Forums.

What I think you can do in this case that you have the measured Zernike coefficients of specific patients but you don’t have any anatomical data on their eyes, you can start with an average eye model like the ones used in these articles:
OpticStudio models of the human eye – Knowledgebase (zemax.com)
How to model the human eye in OpticStudio – Knowledgebase (zemax.com)
Then you can modify the front surface of the lens, right after the pupil, i.e. the STOP in the eye, to be a Zernike surface, and you can optimize the coefficients of that Zernike surface so that the monochromatic OPD equals the measured wavefront shape at the reference wavelength. For the optimization you can use the ZERN optimization operands and set the targets based on the measurement results. We discussed this personalization process of eye models in detail in this paper:
Simulation of visual acuity by personalizable neuro-physiological model of the human eye | Scientific Reports (nature.com)

Finally, I would like to refer to this knowledgebase article to review the details of wavefront measurements using Shack-Hartmann sensors:
Modelling of a Shack-Hartmann Sensor for eye aberration evaluation – Knowledgebase (zemax.com)

I hope this helps, but if you have any further questions, please ask.

Best,
Csilla