Hi Luca,

You might want to try changing the directory mentioned in this post. Hopefully, it will help.

Matlab examples failing to connect to OpticStudio | Zemax Community

That part of the code works well, the error appears when I try to execute the line

I have exactly the same issue.

Waiting for a solution from Zemax

Hi all,

Updating MATLAB to the latest version should resolve this issue. Please try updating and let us know how it goes.

下载 MATLAB、Simulink、Stateflow 和其他 MathWorks 产品

Julia

Hi all, 
I am facing the same problem and updating to the latest Matlab (ie version R2024b) did not solve the problem. The method CreateNewApplication()results in the same error: 

Message: Could not load file or assembly 'ZemaxEngine.dll' or one of its dependencies. A dynamic link library
(DLL) initialization routine failed. (Exception from HRESULT: 0x8007045A)
Source: mscorlib
HelpLink: None

FYI, I am using OpticStudio 2025.

Hi bostanem,

Would you please try the version below?  

Julia 

Hi Julia, 
Thanks a lot. It seems that I can install Update 5 (and not 4). Would that be okay?

Hi bostanem,

I just updated my Matlab to Update5, I experience no error with this version. 

Thanks Julia, this seems to fix the issue for me. I appreciate your help. 

Date: April 29, 2025.

The latest available from Matlab is now R2024b, update 6 (not 5).   When I install update 6 of Matlab, I have the same problem, using the sample scripts from Zemax:

success = ZOSAPI_NetHelper.ZOSAPI_Initializer.Initialize();

returns 0 instead of a 1.

Hi Bowen,

Thank you for your update in the forum post. I'm sharing it here for the reference of other users.

ZOS-API Initialization Error in Matlab | Zemax Community